Effect of Tumstatin on Hypertrophic Scar in the Rabbit Model
نویسندگان
چکیده
This paper aimed to investigate the effect of tumstatin on hypertrophic scar in the rabbit model to explore a new treatment method for hypertrophic scar. An animal model of hypertrophic scar on the rabbit ears was established and was intervened with tumstatin via local injection. The rabbits were randomly assigned into tumstatin group, endostatin group, triamcinolone acetonide group and the saline control group. At 5 days after epithelization, 4 ml of tumstatin, endostatin, triamcinolone acetonide and the saline with concentration of 200 ug/ ml were injected into tissue of scar along the perimeter of the scar in the four experimental groups, respectively. After 30 days of injection, the gross appearance of scar was observed and the blood flow of hyperplastic scar was assessed by laser Doppler flowmetry. The scar tissues on the bilateral ears of each rabbits were resected afterwards. The histological features of scar tissue were examined with HE staining, and the scar thickness was also measured under microscope. The blood flow, vessel density and the scar thickness in the tumstatin group were significantly lower than that in the other three groups, and the difference is statistically significant (P<0.05). Tumstatin may inhibit angiogenesis in hypertrophic scar by means of blocking endothelium proliferation and promoting its apoptosis, have a promising application in the prevention of human hypertrophic scar, which may serve as a promising role in the prevention of human hypertrophic scar. [Yi-lun Liu, Jing Sun, Tuan-jie Hou, Shu-rong Li, Feng-mei Deng, Hai-rong Liu, Yue-ming Liu, Xin-lian Liu, Juan Li. Effect of Tumstatin on Hypertrophic Scar in the Rabbit Model. Life Science Journal. 2012;9(2):25-29] (ISSN:1097-8135). http://www.lifesciencesite.com. 5
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